Faculty Information - HASHIMOTO Mitsuru

（Last updated : 2024-03-12 16:55:15）

HASHIMOTO Mitsuru
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Associate professor

Research Field (Keyword)

Physical pharmaceutical science, Biological system pharmaceutical science, Clinical pharmaceutical science, Drug development chemistry (Key Word：transporter, drug disposition, drug metabolism, mitochondria)

Research Subject

1.	2006/04～	Functional study of mitochondrial solute transporter family proteins and the application for drug discovery (Key Word : mitochondria, transporter, enegetic metabolism, uncoupling)
2.	2006/04～	Structure and function of drug metabolism enzymes for development of prodrugs (Key Word : )

Work experience /Academic appointments

1.	1999/04～2002/05	Michigan State University Department of Biochemistry and molecular Biology, Research Associate
2.	2002/05～2006/03	Kumamoto University Faculty of Pharmaceutical Sciences Department of Pathopharmacology, Research Associate
3.	2006/04～	Matsuyama University College of Pharmaceutical Sciences Department of Pharmceutics, Associate Professor

Publications

1.	2017/04	Article	Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity (Collaboration)
2.	2017/01	Article	Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning (Collaboration)
3.	2014/02	Article	Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. (Collaboration)
4.	2013/06	Article	Involvement of carboxylesterase in hydrolysis of propranolol prodrug during permeation across rat skin (Collaboration)
5.	2012/02	Article	Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1(CPT1b) (Collaboration)
6.	2010/02	Article	Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier (Collaboration)
7.	2008/03	Article	Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier (Collaboration)
8.	2007/07	Article	An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure (Collaboration)
9.	2007/07	Article	Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum (Collaboration)
10.	2006/05	Article	Roles of adjoining Asp and Cys residues of first matrix-facing loop in transport activity of yeast and bovine mitochondrial ADP/ATP carriers (Collaboration)
11.	2005/02	Article	Identification of Esterases Expressed in Caco-2 Cells and Effects of Their Hydrolyzing Activity in Predicting Human Intestinal Absorption (Collaboration)
12.	2002/03	Article	Kinetic and Regulatory Properties of HK 1+, a Modified Form of the Type I Isozyme of Mammalian Hexokinase in Which Interactions between the N- and C-Terminal Halves Have Been Disrupteds (Collaboration)
13.	2001/07	Article	Significant Expression of the Functional Human Type 1 Mitochondrial ADP/ADP Carrier in Yeast Mitochondria (Collaboration)
14.	2001/08	Article	Significant Effect of the N-terminal Region of the Mitochondrial ADP/ADP Carrier on Its Efficient Expression in Yeast Mitochondria (Collaboration)
15.	2000/12	Article	Membrane Potential-Department Conformational Changes in Mitochondrially-Bound Hexokinase of Rat Brain (Collaboration)
16.	2000/07	Article	Irreversible Extrusion of Matrix Facing First Loop of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling of Cys56 Residue with the SH-reagent Methyl Methanthiosulfonate (Collaboration)
17.	1999/01	Article	Expression of Bovine Heart Mitochondrial ADP/ATP Carrier in Yeast Mitochondria Significantly Enhanced Expression by Replacement of the N-terminal Region of the Bovine Carrier by the Corresponding Region of the Yeast carriers (Collaboration)
18.	1999/01	Article	Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys56 Residues by Bifunctional Dimaleimides (Collaboration)
19.	1999/09	Article	Functional Expression of the Tandem-Repeated Homodimer of the Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae (Collaboration)
20.	1995/12	Article	Translation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline (Collaboration)
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