Faculty Information - HASHIMOTO Mitsuru

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Research Field (Keyword)

Research Subject

Work experience /Academic appointments

Publications

Academic conference presentation

（Last updated : 2024-03-12 16:55:15）

HASHIMOTO Mitsuru
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Associate professor

Research Field (Keyword)

Pharmaceutical analytical chemistry and physicochemistry, Pharmaceutical hygiene and biochemistry, Clinical pharmacy, Pharmaceutical chemistry and drug development sciences (Key Word：transporter, drug disposition, drug metabolism, mitochondria)

Research Subject

1.	2006/04～	Functional study of mitochondrial solute transporter family proteins and the application for drug discovery (Key Word : mitochondria, transporter, enegetic metabolism, uncoupling)
2.	2006/04～	Structure and function of drug metabolism enzymes for development of prodrugs (Key Word : )

Work experience /Academic appointments

1.	1999/04～2002/05	Michigan State University Department of Biochemistry and molecular Biology, Research Associate
2.	2002/05～2006/03	Kumamoto University Faculty of Pharmaceutical Sciences Department of Pathopharmacology, Research Associate
3.	2006/04～	Matsuyama University College of Pharmaceutical Sciences Department of Pharmceutics, Associate Professor

Publications

1.	2017/04	Article	Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity Comp Biochem Physiol C Toxicol Pharmacol 194,pp.22-27 (Collaboration)
2.	2017/01	Article	Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning 32,pp.1-9 (Collaboration)
3.	2014/02	Article	Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. Drug Metab Dispos. 42(2),pp.264-273 (Collaboration)
4.	2013/06	Article	Involvement of carboxylesterase in hydrolysis of propranolol prodrug during permeation across rat skin Pharmaceutics pp.371-384 (Collaboration)
5.	2012/02	Article	Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1(CPT1b) Protein Expression & Purification (Collaboration)
6.	2010/02	Article	Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier YAKUGAKU ZASSHI pp.199-204 (Collaboration)
7.	2008/03	Article	Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier Mitochondrion pp.196-204 (Collaboration)
8.	2007/07	Article	An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure Pharmaceutical Research pp.1283-1289 (Collaboration)
9.	2007/07	Article	Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum Drug Metabolism and Disposition pp.1089-1095 (Collaboration)
10.	2006/05	Article	Roles of adjoining Asp and Cys residues of first matrix-facing loop in transport activity of yeast and bovine mitochondrial ADP/ATP carriers Journal of Biochemistry pp.575-582 (Collaboration)
11.	2005/02	Article	Identification of Esterases Expressed in Caco-2 Cells and Effects of Their Hydrolyzing Activity in Predicting Human Intestinal Absorption Drug Metabolism and Disposition pp.1185-1190 (Collaboration)
12.	2002/03	Article	Kinetic and Regulatory Properties of HK 1+, a Modified Form of the Type I Isozyme of Mammalian Hexokinase in Which Interactions between the N- and C-Terminal Halves Have Been Disrupteds Archives of Biochemistry and Biophysics pp.109-115 (Collaboration)
13.	2001/07	Article	Significant Expression of the Functional Human Type 1 Mitochondrial ADP/ADP Carrier in Yeast Mitochondria Biological and Pharmaceutical Bulletin pp.595-599 (Collaboration)
14.	2001/08	Article	Significant Effect of the N-terminal Region of the Mitochondrial ADP/ADP Carrier on Its Efficient Expression in Yeast Mitochondria Journal of Biological Chemistry pp.28881-28888 (Collaboration)
15.	2000/12	Article	Membrane Potential-Department Conformational Changes in Mitochondrially-Bound Hexokinase of Rat Brain Archive of Biochemistryand Biophysics pp.163-173 (Collaboration)
16.	2000/07	Article	Irreversible Extrusion of Matrix Facing First Loop of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling of Cys56 Residue with the SH-reagent Methyl Methanthiosulfonate Journal of Biochemistry (Tokyo) pp.443-449 (Collaboration)
17.	1999/01	Article	Expression of Bovine Heart Mitochondrial ADP/ATP Carrier in Yeast Mitochondria Significantly Enhanced Expression by Replacement of the N-terminal Region of the Bovine Carrier by the Corresponding Region of the Yeast carriers pp.113-124 (Collaboration)
18.	1999/01	Article	Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys56 Residues by Bifunctional Dimaleimides Biochemistry pp.1050-1056 (Collaboration)
19.	1999/09	Article	Functional Expression of the Tandem-Repeated Homodimer of the Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae Bhiochemical Biophysical Research Communication pp.726-730 (Collaboration)
20.	1995/12	Article	Translation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline Journal of Biological Chemistry pp.29548-29554 (Collaboration)
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Academic conference presentation

2022/03/27

Mechanism of Inhibition of Human Carobxylesterase by Flavonoids