Research Field (Keyword)
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Clinical pharmacy, Pharmaceutical chemistry and drug development sciences, Pharmaceutical hygiene and biochemistry, Pharmaceutical analytical chemistry and physicochemistry (Key Word：drug metabolism,, mitochondria, transporter, drug disposition,)
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Research Subject
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2006/04～
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Structure and function of drug metabolism enzymes for development of prodrugs (Key Word : )
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2006/04～
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Functional study of mitochondrial solute transporter family proteins and the application for drug discovery (Key Word : mitochondria, transporter, enegetic metabolism, uncoupling)
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Work experience /Academic appointments
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1.
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2006/04～
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Matsuyama University College of Pharmaceutical Sciences Department of Pharmceutics, Associate Professor
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2.
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2002/05～2006/03
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Kumamoto University Faculty of Pharmaceutical Sciences Department of Pathopharmacology, Research Associate
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3.
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1999/04～2002/05
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Michigan State University Department of Biochemistry and molecular Biology, Research Associate
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Publications
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1.
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2017/04
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Article
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Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity Comp Biochem Physiol C Toxicol Pharmacol 194,pp.22-27 (Collaboration)
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2.
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2017/01
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Article
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Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning 32,pp.1-9 (Collaboration)
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3.
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2014/02
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Article
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Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. Drug Metab Dispos. 42(2),pp.264-273 (Collaboration)
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4.
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2013/06
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Article
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Involvement of carboxylesterase in hydrolysis of propranolol prodrug during permeation across rat skin Pharmaceutics pp.371-384 (Collaboration)
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5.
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2012/02
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Article
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Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1(CPT1b) Protein Expression & Purification (Collaboration)
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6.
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2010/02
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Article
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Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier YAKUGAKU ZASSHI pp.199-204 (Collaboration)
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7.
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2008/03
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Article
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Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier Mitochondrion pp.196-204 (Collaboration)
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8.
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2007/07
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Article
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An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure Pharmaceutical Research pp.1283-1289 (Collaboration)
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9.
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2007/07
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Article
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Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum Drug Metabolism and Disposition pp.1089-1095 (Collaboration)
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10.
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2006/05
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Article
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Roles of adjoining Asp and Cys residues of first matrix-facing loop in transport activity of yeast and bovine mitochondrial ADP/ATP carriers Journal of Biochemistry pp.575-582 (Collaboration)
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11.
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2005/02
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Article
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Identification of Esterases Expressed in Caco-2 Cells and Effects of Their Hydrolyzing Activity in Predicting Human Intestinal Absorption Drug Metabolism and Disposition pp.1185-1190 (Collaboration)
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12.
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2002/03
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Article
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Kinetic and Regulatory Properties of HK 1+, a Modified Form of the Type I Isozyme of Mammalian Hexokinase in Which Interactions between the N- and C-Terminal Halves Have Been Disrupteds Archives of Biochemistry and Biophysics pp.109-115 (Collaboration)
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13.
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2001/07
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Article
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Significant Expression of the Functional Human Type 1 Mitochondrial ADP/ADP Carrier in Yeast Mitochondria Biological and Pharmaceutical Bulletin pp.595-599 (Collaboration)
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14.
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2001/08
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Article
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Significant Effect of the N-terminal Region of the Mitochondrial ADP/ADP Carrier on Its Efficient Expression in Yeast Mitochondria Journal of Biological Chemistry pp.28881-28888 (Collaboration)
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15.
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2000/12
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Article
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Membrane Potential-Department Conformational Changes in Mitochondrially-Bound Hexokinase of Rat Brain Archive of Biochemistryand Biophysics pp.163-173 (Collaboration)
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16.
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2000/07
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Article
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Irreversible Extrusion of Matrix Facing First Loop of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling of Cys56 Residue with the SH-reagent Methyl Methanthiosulfonate Journal of Biochemistry (Tokyo) pp.443-449 (Collaboration)
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17.
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1999/01
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Article
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Expression of Bovine Heart Mitochondrial ADP/ATP Carrier in Yeast Mitochondria Significantly Enhanced Expression by Replacement of the N-terminal Region of the Bovine Carrier by the Corresponding Region of the Yeast carriers pp.113-124 (Collaboration)
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18.
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1999/01
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Article
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Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys56 Residues by Bifunctional Dimaleimides Biochemistry pp.1050-1056 (Collaboration)
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19.
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1999/09
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Article
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Functional Expression of the Tandem-Repeated Homodimer of the Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae Bhiochemical Biophysical Research Communication pp.726-730 (Collaboration)
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20.
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1995/12
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Article
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Translation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline Journal of Biological Chemistry pp.29548-29554 (Collaboration)
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21.
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2006/11
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Other
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The transport activity via human oligopeptide transporter(h-PEPT1) is regulated by the protonation/deprotonation state of the most crucial histidine His57 (Collaboration)
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22.
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2004/10
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Other
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Alteration of substrate specificity of the human type 1 carboxylesterase on replacements of restricted regions on corresponding region of the rat isozymes
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23.
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2004/06
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Other
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Precision of Intestinal Permeability of ester prodrug predicted in Caco-2 cell monolayer Kyoto, JAPAN
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24.
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2004/05
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Other
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Difference of Substrate Specificity among Carboxylesterase Isozymes Kyoto, JAPAN
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25.
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2003/10
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Other
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Characterization and Comparison of Substrate Specificity in Carboxylesterase Isozymes
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26.
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2000/08
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Other
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Membrane Potential-Dependent Conformational Changes in Mitochondrially-Bound Hexokinase of Brain Oxford, ENGLAND
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Display 5 items
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Display all(26)
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Academic conference presentation
| 1. |
2026/03/27 |
Inhibitory Effect of Miquelianin on CDDP-Induced Renal Tubular Epithelial Cell Death
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| 2. |
2023/03/26 |
Inhibitory mechanism of flavonoids in human carboxylesterases
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| 3. |
2022/03/27 |
Mechanism of Inhibition of Human Carobxylesterase by Flavonoids
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Faculty Information
