Faculty Information - OKUYAMA Satoshi

Educational Background

Work experience /Academic appointments

Academic Awards

Membership of Professional Organizations

Publications

Invited Lectures

（Last updated : 2025-02-12 18:33:28）

OKUYAMA Satoshi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Professor

Educational Background

1.	1995/04～1999/03	Faculty of Pharmaceutical Science, Tokyo University of Pharmacy and Life Science, Graduated,
2.	1999/04～2001/03	Graduate School, Division of Nutritional and Environmental Scieces, University of Shizuoka, Completed,
3.	2001/04～2004/03	Graduate School, Division of Nutritional and Environmental Scieces, University of Shizuoka, Completed,

Work experience /Academic appointments

1.	2005/01～2007/02	CANADA University of Saskatchewan, College of Pharmacy and Nutrition, Postdoctoral Fellow
2.	2007/03～2009/03	USA University of Nebraska Medical Center, College of Medicine, Postdoctoral Research Associate

Academic Awards

2005/01

Saskatchewan Health Research Foundation, Postdoctoral Research Fellowships (2004-2005)

Membership of Professional Organizations

2008/05～

Society for Neuroscience

Publications

1.	2025/02	Article	Reduction in MCP-1 production in preadipocytes is mediated by PPARγ activation and JNK/SIRT1 signaling (Collaboration)
2.	2024/11	Article	Anti-Inflammatory and Neurotrophic Factor Production Effects of 3,5,6,7,8,3',4'-Heptamethoxyflavone in the Hippocampus of Lipopolysaccharide-Induced Inflammation Model Mice (Collaboration)
3.	2024/10	Article	Cloperastine Reduces IL-6 Expression via Akt/GSK3/Nrf2 Signaling in Monocytes/Macrophages and Ameliorates Symptoms in a Mouse Sepsis Model Induced by Lipopolysaccharide (Collaboration)
4.	2024/03	Article	Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice (Collaboration)
5.	2024/01	Article	Sulconazole induces pyroptosis promoted by interferon-γ in monocyte/macrophage lineage cells (Collaboration)
6.	2023/10	Article	Isolation and mechanism analysis of functional ingredients in citrus fruits from Ehime prefecture : Aiming for utilization of local resources (Collaboration)
7.	2023/03	Article	Effects of Citrus kawachiensis Peel in Frailty-like Model Mice Induced by Low Protein Nutrition Disorders (Collaboration)
8.	2023/02	Article	N-Caffeoyltryptophan enhances adipogenic differentiation in preadipocytes and improves glucose tolerance in mice. (Collaboration)
9.	2022/08	Article	Ibudilast Reduces IL-6 Levels and Ameliorates Symptoms in Lipopolysaccharide-Induced Sepsis Mice (Collaboration)
10.	2022/07	Article	Activation of Extracellular Signal-Regulated Kinase 2 and cAMP Response Element-Binding Protein in Cultured Neurons by the Macrocyclic Ellagitannin Oenothein B (Collaboration)
11.	2022/05	Article	The Beneficial Effects of Citrus kawachiensis Peel on Neurogenesis in the Hippocampus and Gut Microbiota Changes in a Chronic Unpredictable Mild Stress Mouse Model. (Collaboration)
12.	2021/12	Article	Neuroprotective and Anti-Microglial Activation Effects of Tocotrienols in Brains of Lipopolysaccharide-Induced Inflammatory Model Mice (Collaboration)
13.	2021/10	Article	Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells (Collaboration)
14.	2021/05	Article	Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain (Collaboration)
15.	2021/04	Article	T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning (Collaboration)
16.	2021/01	Article	Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food (Collaboration)
17.	2020/10	Article	Cynandione A induces adipogenesis and beige adipocyte-related phenotype in 3T3-L1 cells. (Collaboration)
18.	2020/01	Article	Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation. (Collaboration)
19.	2019/12	Article	Heptamethoxyflavone inhibits adipogenesis via enhancing PKA signaling. (Collaboration)
20.	2019/12	Article	T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics. (Collaboration)
21.	2019/08	Article	Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. (Collaboration)
22.	2019/04	Article	Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. (Collaboration)
23.	2019/04	Article	Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells. (Collaboration)
24.	2019/02	Article	Auraptene/Naringin-Rich Fruit Juice of Citrus kawachiensis (Kawachi Bankan) Prevents Ischemia-Induced Neuronal Cell Death in Mouse Brain through Anti-Inflammatory Responses. (Collaboration)
25.	2018/08	Article	Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice. (Collaboration)
26.	2018/08	Article	Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. (Collaboration)
27.	2018/07	Article	Auraptene in the Peels of Citrus Kawachiensis (Kawachibankan) Contributes to the Preservation of Cognitive Function: A Randomized, Placebo-Controlled, Double-Blind Study in Healthy Volunteers. (Collaboration)
28.	2018/07	Article	Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice. (Collaboration)
29.	2018/05	Article	The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. (Collaboration)
30.	2017/12	Article	Heptamethoxyflavone Reduces Phosphodiesterase Activity and T-Cell Growth in vitro. (Collaboration)
31.	2017/10	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation. (Collaboration)
32.	2017/08	Article	Sansoninto as evidence-based remedial medicine for depression-like behavior. (Collaboration)
33.	2017/02	Article	Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity (Collaboration)
34.	2016/10	Article	Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease (Collaboration)
35.	2016/09	Article	Phenotypes associated with psychiatric disorders are sex-specific in a mutant mouse line (Collaboration)
36.	2016/04	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus. (Collaboration)
37.	2016/03	Article	Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination. (Collaboration)
38.	2016/01	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice. (Collaboration)
39.	2015/11	Article	Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain. (Collaboration)
40.	2015/10	Other	The effect of bioactive substances from citrus on the central nervous system and the expansion as food materials. (Single)
41.	2015/09	Article	Nobiletin Induces Oligodendrocyte Lineage Precursor Cells in a Cuprizone-Administered Demyelination Animal Model. (Collaboration)
42.	2015/04	Article	3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus. (Collaboration)
43.	2015/04	Article	Edaravone enhances brain-derived neurotrophic factor production in the ischemic mouse brain. (Collaboration)
44.	2014/08	Article	Imipramine Ameliorates Pain-related Negative Emotion via Induction of Brain-derived Neurotrophic Factor. (Collaboration)
45.	2014/05	Article	Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain (Collaboration)
46.	2014/03	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model (Collaboration)
47.	2014/02	Article	Dilation of the inferior colliculus and hypersensitivity to sound inWnt1-cre and Wnt1-GAL4 double-transgenic mice (Collaboration)
48.	2013/09	Article	Characterization of Constituents in the Peel of Citrus kawachiensis (Kawachibankan). (Collaboration)
49.	2013/09	Article	Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination. (Collaboration)
50.	2013/08	Article	Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia (Collaboration)
51.	2013/05	Article	Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain. (Collaboration)
52.	2013/03	Article	A comparative study of axon-surrounding cells in the two nasal nerve tracts from mouse olfactory epithelium and vomeronasal organ. (Collaboration)
53.	2013/01	Article	Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice. (Collaboration)
54.	2013/01	Article	Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice. (Collaboration)
55.	2012/10	Article	Effect of Citrus polymethoxyfavones on neuritogenesis in neuroblastoma cells. (Collaboration)
56.	2012/10	Article	Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice. (Collaboration)
57.	2012/04	Article	Neurotrophic Effect of Citrus Auraptene: Neuritogenic Activity in PC12 Cells (Collaboration)
58.	2012/02	Article	Isolation and Characterization of Activators of ERK/MAPK from Citrus Plants. (Collaboration)
59.	2012/01	Article	Effect of the edible mushroom Mycoleptodonoides aitchisonii on transient global ischemia-induced monoamine metabolism changes in rat cerebral cortex. (Collaboration)
60.	2011/03	Article	Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages. (Collaboration)
61.	2010/10	Article	Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. (Collaboration)
62.	2010/10	Article	Estrogen Stimulates Proliferation and Differentiation of Neural Stem/Progenitor Cells through Different Signal Transduction Pathways. (Collaboration)
63.	2010/08	Article	CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. (Collaboration)
64.	2010/08	Article	Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. (Collaboration)
65.	2010/02	Article	4-Methylcatechol-induced heme oxygenase-1 exerts a protective effect against oxidative stress in cultured neural stem/progenitor cells via PI3 kinase/Akt pathway. (Collaboration)
66.	2009/12	Article	Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. (Collaboration)
67.	2009/03	Article	YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (Collaboration)
68.	2008/12	Article	Spatial learning impairment, enhanced CDK5/p35 activity, and down-regulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. (Collaboration)
69.	2008/08	Article	Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectomized female rats fed genistein. (Collaboration)
70.	2007/02	Article	Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats. (Collaboration)
71.	2006/02	Article	Flavor Components of Monoterpenes in Citrus Essential oils Enhance the Release of Monoamines from Rat Brain Slices. (Collaboration)
72.	2004/10	Article	Mycoleptodonoides aitchisonii affects brain nerve growth factor concentration in newborn rats. (Collaboration)
73.	2004/06	Article	Effect of adding dietary methionine to a low soy protein diet on the brain protein synthesis rate in ovariectomized female rats (Collaboration)
74.	2004/04	Article	Conductor compounds of phenylpentane in Mycoleptodonoides aitchisonii mycelium enhance the release of dopamine from rat brain striatum slices. (Collaboration)
75.	2004/02	Article	Enhancing effect of Mycoleptodonoides aitchisonii on synthesis of nerve growth factor and releasing dopamine in the rat brain. (Collaboration)
76.	2002/07	Article	Dietary genistein affects brain protein synthesis rates in ovariectomized female rats. (Collaboration)
77.	2002/03	Article	Effect of dietary protein quantity and quality on the brain protein synthesis rate in ovariectomized female rats. (Collaboration)
78.	2002/02	Article	Effects of quantity and quality of dietary protein on the brain polysome profile in aged rats. (Collaboration)
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Invited Lectures

1.	2015/08	Neuroprotective effect of heptamethoxyflavone in the mouse brain (Symposium, 250th American Chemical Society National Meeting, Boston, USA)
2.	2014/08	A Citrus Flavonoid on Protection against Memory Impairment and Neuronal Cell Death in a Global Cerebral Ischemia (13th International Symposium on Spinal Cord Sciences, Ube, Yamaguchi)