Faculty Information - AKIRA Kazuki | Matsuyama University

（Last updated : 2024-04-04 17:15:31）

AKIRA Kazuki
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Professor

Publications

1.	2021/08	Article	Application of quantitative NMR spectroscopy to the quality evaluation of diclofenac gargles as hospital preparations (Collaboration)
2.	2023/08	Article	A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide (Collaboration)
3.	2022/11	Article	Study on the use of ozone water as a chemical decontamination agent for antineoplastic drugs in clinical settings (Collaboration)
4.	2024/01	Article	Preparation of [1'-¹³C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux (Collaboration)
5.	2023/12	Article	Analysis of the vibrioferrin biosynthetic pathway of Vibrio parahaemolyticus (Collaboration)
6.	2021/10	Article	Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings (Collaboration)
7.	2014/08	Article	Synthesis of ¹³C-Lidocaine as a Probe of Breath Test for the Evaluation of Cytochrome P450 Activity (Collaboration)
8.	2013/11	Article	Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using ¹H NMR spectroscopic urinalysis (Collaboration)
9.	2013/09	Article	An efficient laboratory-scale preparative method for [1-¹³C]glycocholic acid (Collaboration)
10.	2012/07	Article	Sample preparation method to minimize chemical shift variability for NMR-based urinary metabonomics of genetically hypertensive rats (Collaboration)
11.	2012/04	Article	A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on ¹H NMR spectroscopic urinalysis (Collaboration)
12.	2010/01	Article	LC-NMR identification of a novel taurine-related metabolite observed in¹H NMR-based metabonomics of genetically hypertensive rats (Collaboration)
13.	2008/02	Article	¹H NMR-based Metabonomic Analysis of Urine from Young Spontaneously Hypertensive Rats (Collaboration)
14.	2006/01	Article	Inhibitory Effects of Amlodipine and Fluvastatin on the Deposition of Advanced Glycation End Products in Aortic Wall of Cholesterol and Fructose-Fed Rabbits (Collaboration)
15.	2005/05	Article	Investigations into Biochemical Changes of Genetic Hypertensive Rats Using ¹H Nuclear Magnetic Resonance-based Metabonomics (Collaboration)
16.	2005/02	Article	Use of ¹³C-Labeling and NMR Spectroscopy for the Investigation of Degradation Pathways of Amadori Compounds (Collaboration)
17.	2004/02	Article	Determination of Urinary Glyoxal and Methylglyoxal by High-performance Liquid Chromatography (Collaboration)
18.	2002/01	Article	Rapid Internal Acyl Migration and Protein Binding of Synthetic Probenecid Glucuronides (Collaboration)
19.	2001/07	Article	Kinetics of Intramolecular Acyl Migration of 1$\beta$-O-Acyl Glucuronides of (R)-and (S)-2-Phenylpropionic Acids (Collaboration)
20.	2001/06	Article	Direct Nuclear Magnetic Resonance Spectroscopic Analysis of ¹³C-Labeled Antipyrine Metabolites in Human Urine (Collaboration)
21.	2001/03	Article	Hippuric Acid Test Using ¹³C-Labelling and NMR Spectroscopy (Collaboration)
22.	2000/04	Article	Stereoselective Internal Acyl Migration of 1$\beta$-\textit{O}-Acyl Glucuronides of Enantiomeric 2-Phenylpropionic Acids (Collaboration)
23.	1999/11	Article	Direct Detection of Antipyrine Metabolites in Rat Urine by ¹³C Labeling and NMR Spectroscopy (Collaboration)
24.	1998/05	Article	Studies on the Stereoselective Internal Acyl Migration of Ketoprofen Glucuronides Using ¹³C-Labeling and Nuclear Magnetic Resonance Spectroscopy (Collaboration)
25.	1997/12	Article	Evaluation of Liver Function by Co-administration Methodology Using ¹³C-Labelled Benzoic Acid and Hippuric Acid Coupled with Nuclear Magnetic Resonance Spectroscopy (Collaboration)
26.	1997/06	Article	Direct Detection of the Internal Acyl Migration Reactions of Benzoic Acid 1-O- Acylglucuronide by ¹³C-Labeling and Nuclear Magnetic Resonance Spectroscopy (Collaboration)
27.	1997/01	Article	Preparation of 1-O-Acylglucuronides of ¹³C-Labelled(R)-and(S)-Ketoprofens (Collaboration)
28.	1996/11	Article	Direct Determination of Diastereomeric¹³C-Labeled Ketoprofen Glucuronides in Human Urine by Nuclear Magnetic Resonance Spectroscopy (Collaboration)
29.	1996/01	Article	NMR Spectroscopic and Theoretical Chemistry Studies on the Internal Acyl Migration Reactions of the 1-O-Acyl-$\beta$-D-glucopyranuronate Conjugates of 2-,3-,and 4-(Trifluoromethyl)benzoic Acids (Collaboration)
30.	1995/05	Article	Use of Nuclear Magnetic Resonance Spectroscopy and Selective ¹³C-Labeling for Pharmacokinetic Research in Man:Detection of Benzoic Acid Conversion to Hippuric Acid (Collaboration)
31.	1995/01	Article	Synthesis of Selectively ¹³C-Labelled Benzoic Acid for Nuclear Magnetic Resonance Spectroscopic Measurement of Glycine Conjugation Activity (Collaboration)
32.	1994/09	Article	High-Field Deuterium Nuclear Magnetic Resonance Spectroscopic Monitoring of the Pharmacokinetics of Selectively Deuterated Benzoic Acid in Man (Collaboration)
33.	1994/03	Article	Application of Radioluminography to Off-Line Counting of Radioactivity in High-Performance Liquid Chromatographic Eluates (Collaboration)
34.	1993/04	Article	Profiling of Arachidonic Acid Metabolites in Rabbit Platelets by Radio Gas Chromatography (Collaboration)
35.	1993/01	Book	Radio-Gas-Chromatography of Lipids (Collaboration)
36.	1990/08	Article	Use of Radio-Gas Chromatography and Tritium Label to Optimize Derivatization Procedures (Collaboration)
37.	1989/05	Article	Radio-Gas Chromatography on Wide-Bore Capillary Columns Equipped with a Synchronized Accumulating Radioisotope Detector (Collaboration)
38.	1989/04	Article	Improved Synchronized Accumulating Radioisotope Detector for Gas Chromatography (Collaboration)
39.	1988/08	Article	Quantitative Determination of Nifedipine and Its Metabolite in Hamster Plasma by Radio-Gas Chromatography (Collaboration)
40.	1986/10	Article	Synchronized Accumulating Radioisotope Detector Equipped with a Mutual Anti-Coincidence Guard for Radio-Gas Chromatography (Collaboration)
41.	1985/06	Article	Application of Radioisotope Tracer Techniques to Analytical Gas Chromatography: Determination of Gas Chromatographic Peak Yield (Collaboration)
42.	1983/12	Article	Studies Related to $\beta$-Lactam Antibiotics.IX.Alcoholysis of a 4-Oxa-1-azabicyclo[3.2.0]heptane-3,7-dione (Collaboration)
43.	1983/01	Article	Studies Related to$\beta$-lactam Antibiotics.Part 8.AFacile Acid-Catalyzed Ring Transfomation of l-Dethia-1-oxa-5-epiisiabgtdripenicillins into Oxazolinones (Collaboration)
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Invited Lectures

2019/10

Syntheses of compounds labeled with stable isotope ¹³C and application to metabolic analyses (Tokyo)