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MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Associate professor |
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| Language | English |
| Publication Date | 2022/08 |
| Type | |
| Peer Review | With peer review |
| Title | Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings |
| Contribution Type | |
| Journal | Journal of Oncology Pharmacy Practice |
| Publisher | Sage Publications Ltd. |
| Volume, Issue, Pages | 28(8),pp.1781-1789 |
| Author and coauthor | Kato, Ginjiro; Mitome, Hidemichi; Shigematsu, Saki; Utsunomiya, Aya; Shimasaki, Miho; Sasaki, Yuta; Maki, Tsuneo; Yamamoto, Hiroshi; Tanabe, Tomotaka; Funahashi, Tatsuya; Hatae, Noriyuki; Hidaka, Noriaki; Tanaka, Mamoru; Akira, Kazuki |
| Details | In this study, the degradation and inactivation efficacy of ozone water, which has newly been introduced for decontamination of antineoplastic drugs in spills, was investigated for formulations of gemcitabine, irinotecan, and paclitaxel. Ozone water was shown to be effective as a decomposition agent for the antineoplastic drug formulations examined, although the efficacy depends on the chem. structures of the drugs and the pharmaceutical additives. It was also suggested that ozone treatment has a tendency to decrease the toxicity of the antineoplastic drug formulations. As such, further studies are required in order to clarify the effects and application limitations of ozone water. |