ミトメ　ヒデミチ   MITOME Hidemichi   見留　英路    所属   松山大学  薬学部 医療薬学科    職種   准教授
言語種別	英語
発行・発表の年月	2022/08
形態種別	学術論文
査読	査読有り
標題	Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings
執筆形態	共著
掲載誌名	Journal of Oncology Pharmacy Practice
出版社・発行元	Sage Publications Ltd.
巻・号・頁	28(8),pp.1781-1789
著者・共著者	Kato, Ginjiro; Mitome, Hidemichi; Shigematsu, Saki; Utsunomiya, Aya; Shimasaki, Miho; Sasaki, Yuta; Maki, Tsuneo; Yamamoto, Hiroshi; Tanabe, Tomotaka; Funahashi, Tatsuya; Hatae, Noriyuki; Hidaka, Noriaki; Tanaka, Mamoru; Akira, Kazuki
概要	In this study, the degradation and inactivation efficacy of ozone water, which has newly been introduced for decontamination of antineoplastic drugs in spills, was investigated for formulations of gemcitabine, irinotecan, and paclitaxel. Ozone water was shown to be effective as a decomposition agent for the antineoplastic drug formulations examined, although the efficacy depends on the chem. structures of the drugs and the pharmaceutical additives. It was also suggested that ozone treatment has a tendency to decrease the toxicity of the antineoplastic drug formulations. As such, further studies are required in order to clarify the effects and application limitations of ozone water.
DOI	https://doi.org/10.1177/10781552211042525