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MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Associate professor |
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| Language | English |
| Publication Date | 2016/04 |
| Type | |
| Peer Review | With peer review |
| Title | Amitorines A and B, Nitrogenous Diterpene Metabolites of Theonella swinhoei: Isolation, Structure Elucidation, and Asymmetric Synthesis |
| Contribution Type | |
| Journal | Journal of Natural Products |
| Journal Type | Another Country |
| Publisher | American Chemical Society-American Society of Pharmacognosy |
| Volume, Issue, Pages | 79(4),pp.996-1004 |
| Author and coauthor | Koichiro Ota, Yukiko Hamamoto, Wakiko Eda, Kenta Tamura, Akiyoshi Sawada, Ayako Hoshino, Hidemichi Mitome, Kazuo Kamaike, Hiroaki Miyaoka |
| Details | Two new nitrogenous prenylbisabolanes never before found in Lithistid sponges have been isolated from Theonella swinhoei. These new diterpenes, named amitorine A (1) and amitorine B (2), contg. a prenylbisabolane skeleton have been characterized by spectroscopic analyses, and the relative and abs. configurations of 1 and 2 were detd. by asym. synthesis of both diastereomers via the common bicyclic lactone 6 intermediate. |