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MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Associate professor |
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| Language | English |
| Publication Date | 2014/08 |
| Type | |
| Peer Review | With peer review |
| Title | Synthesis of 13C-lidocaine as a probe of breath test for the evaluation of cytochrome P450 activity |
| Contribution Type | |
| Journal | Chemical & Pharmaceutical Bulletin |
| Journal Type | Another Country |
| Publisher | Pharmaceutical Society of Japan |
| Volume, Issue, Pages | 62(8),pp.806-809 |
| Author and coauthor | Hidemichi Mitome, Erika Sugiyama, Hitoshi Sato, Kazuki Akira |
| Details | 13C-Labeled lidocaine, 2-di[1-13C]ethylamino-N-(2,6-dimethylphenyl)acetamide (1), was synthesized from [1-13C]acetic acid in six steps, as a probe for a breath test to evaluate in vivo cytochrome P450 activity. The measurement of 13CO2 in breath was successfully performed following oral administration of 13C-lidocaine 1 to mice. |