ミトメ　ヒデミチ   MITOME Hidemichi   見留　英路    所属   松山大学  薬学部 医療薬学科    職種   准教授
言語種別	英語
発行・発表の年月	2014/08
形態種別	学術論文
査読	査読有り
標題	Synthesis of 13C-​lidocaine as a probe of breath test for the evaluation of cytochrome P450 activity
執筆形態	共著
掲載誌名	Chemical & Pharmaceutical Bulletin
掲載区分	国外
出版社・発行元	Pharmaceutical Society of Japan
巻・号・頁	62(8),pp.806-809
著者・共著者	Hidemichi Mitome, Erika Sugiyama, Hitoshi Sato, Kazuki Akira
概要	13C-Labeled lidocaine, 2-di[1-13C]ethylamino-N-(2,6-dimethylphenyl)acetamide (1), was synthesized from [1-13C]acetic acid in six steps, as a probe for a breath test to evaluate in vivo cytochrome P450 activity. The measurement of 13CO2 in breath was successfully performed following oral administration of 13C-lidocaine 1 to mice.
DOI	https://doi.org/10.1248/cpb.c14-00250