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MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Associate professor |
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| Publication Date | 2011/12 |
| Type | |
| Peer Review | With peer review |
| Title | Total synthesis of antimalarial diterpenoid (+)-kalihinol A |
| Contribution Type | |
| Journal | Chemical Communications |
| Publisher | Cambridge |
| Volume, Issue, Pages | 901-903頁 |
| Author and coauthor | Hiroaki Miyaoka, Yasunori Abe, Nobuaki Sekiya, Hidemichi Mitome, Etsuko Kawashima |
| Details | Total synthesis of antimalarial diterpenoid (+)-kalihinol A (I), isolated from marine sponge Acanthella sp., is achieved. This total synthesis involves regioselective alkylation of an epoxide, construction of a tetrahydropyran ring by iodo-etherification, construction of a cis-decalin ring by intramol. Diels-Alder reaction, isomerization of cis-decalin to trans-decalin, and subsequent functionalization of the trans-decalin ring. |
| DOI | 10.1039/C1CC16468F |