ミトメ　ヒデミチ   MITOME Hidemichi   見留　英路    所属   松山大学  薬学部 医療薬学科    職種   准教授
発行・発表の年月	2011/12
形態種別	学術論文
査読	査読有り
標題	Total synthesis of antimalarial diterpenoid (+)-kalihinol A
執筆形態	共著
掲載誌名	Chemical Communications
出版社・発行元	Cambridge
巻・号・頁	48(6),901-903頁
著者・共著者	Hiroaki Miyaoka, Yasunori Abe, Nobuaki Sekiya, Hidemichi Mitome, Etsuko Kawashima
概要	Total synthesis of antimalarial diterpenoid (+)-kalihinol A (I), isolated from marine sponge Acanthella sp., is achieved. This total synthesis involves regioselective alkylation of an epoxide, construction of a tetrahydropyran ring by iodo-etherification, construction of a cis-decalin ring by intramol. Diels-Alder reaction, isomerization of cis-decalin to trans-decalin, and subsequent functionalization of the trans-decalin ring.
DOI	10.1039/C1CC16468F