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MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Associate professor |
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| Publication Date | 2011/02 |
| Type | |
| Peer Review | With peer review |
| Title | A formal synthesis of antimalarial diterpenoid 7,20-diisocyanoadociane. |
| Contribution Type | |
| Journal | Chemistry Letters |
| Volume, Issue, Pages | 246-247頁 |
| Author and coauthor | Hiroaki Miyaoka,Yusuke Okubo, Makiko Muroi,Hidemichi Mitome, Etsuko Kawashima. |
| Details | A formal synthesis of antimalarial diterpenoid 7,20-diisocyanoadociane, isolated from marine sponge Adocia sp., was achieved. The authors synthesized Corey's synthetic intermediate 2 for 7,20-diisocyanoadociane. This synthesis involves the synthesis of a perhydropyrene deriv. using a sequential isomerization-intramol. Diels-Alder reaction as the key step. |
| DOI | 10.1246/cl.2011.246 |