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SAKAMOTO Takatoshi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences Position Professor |
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| Language | Japanese |
| Publication Date | 2013/11 |
| Type | |
| Title | Preparation of taste-masked particles with immediate-release property using an ultrahigh-speed mixer |
| Contribution Type | |
| Journal | PHARM TECH JAPAN |
| Publisher | Jiho, Inc. |
| Volume, Issue, Pages | 115-121頁 |
| Details | The objective of this investigation was to prepare the particles for bitter taste masking which released drugs immediately after migration into the gastrointestinal tract. Particles were prepared by mixing the powder mixture with ultrahigh-speed mixer, which was composed of corn starch (CS) as a core particle, acetaminophen (APAP) as a model drug, and Eudragit E PO (EPO) and hydrogenated castor oil (HCO) as coating materials. The surfaces of the dry coated particles were observed with a scanning electron microscope, and the APAP release rate from the particles was determined according to the JP 16 paddle method in distilled water and JP dissolution test 1st fluid (pH 1.2). The resultant coated particles had irregular unevenness on the surfaces, which were a drug-containing matrix layer formed by EPO and HCO. And dissolution test revealed APAP release rate from the particles in water was slower than that in JP dissolution test 1st fluid. Additionally, by overcoating the upper layer of EPO and HCO on the matrix layer, APAP release rate in water was significantly suppressed without little change of the rate in JP dissolution test 1st fluid. This investigation suggests that the particles with a multilayer coating of drug- containing matrix and release-controlling layers using EPO and HCO could be used as an immediate-release dosage form for bitter taste masking. |