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アキヤマ シンジ
AKIYAMA Shinji
秋山 伸二 所属 松山大学 薬学部 医療薬学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2025/10 |
| 形態種別 | 学術論文 |
| 査読 | 査読あり |
| 標題 | Association Between Immunotherapy and Overall Survival in Malnourished Patients with Advanced Non-Small Cell Lung Cancer: A Nationwide Retrospective Cohort Study in Japan |
| 執筆形態 | 共著 |
| 掲載誌名 | Nutrition and Cancer |
| 掲載区分 | 国外 |
| 出版社・発行元 | AYLOR & FRANCIS |
| 巻・号・頁 | 78(1),pp.50-58 |
| 総ページ数 | 9 |
| 担当区分 | 最終著者 |
| 著者・共著者 | Maya Shimasaki, Yasutaka Ihara, Shoichiro Yamamoto, Haruki Takata, Shinji Akiyama |
| 概要 | This nationwide retrospective cohort study investigated the association between nutritional status at the start of first-line immunotherapy and overall survival in patients with advanced non-small cell lung cancer (NSCLC) in Japan. Using a large administrative claims database, the authors analyzed 2,461 patients treated between December 2016 and December 2024. Nutritional status was assessed with the Geriatric Nutritional Risk Index (GNRI), which had a mean value of 93.20 in the study population. Lower GNRI values were associated with progressively worse survival: compared with a GNRI of 100, the hazard ratio for death was 1.64 (95% CI, 1.40-1.93) at a GNRI of 90 and 2.11 (95% CI, 1.71-2.61) at a GNRI of 85. This relationship was consistent across major subgroups, including age, sex, and dysphagia status. The findings suggest that malnutrition is an important prognostic factor in patients with advanced NSCLC receiving immunotherapy, and that routine nutritional assessment and early intervention to maintain GNRI ≥100 may improve survival outcomes. |
| DOI | 10.1080/01635581.2025.2569118 |