タマイ　エイジ   TAMAI Eiji   玉井　栄治    所属   松山大学  薬学部 医療薬学科    職種   教授
発行・発表の年月	2006/09
形態種別	学術論文
査読	査読有り
標題	Optimum preparation of levocarnitine chloride solution in the hospital pharmac
執筆形態	共著
掲載誌名	Yakugaku Zasshi
巻・号・頁	126(9),805-809頁
著者・共著者	Tanaka H, Asakura M, Doi C, Fukuoka N, Tamai E, Miyata S, Matsushita O, Okabe A, Negayama K, Houchi H.
概要	Levocarnitine chloride is used for the therapeutic purpose of levocarnitine deficiency. For infants, however, levocarnitine chloride tablets must be crushed to avoid difficulties associated with swallowing, and also to administer an appropriately low dosage. Since the tablet is extremely hygroscopic and sour, it is dissolved in water containing simple syrup after crushing. In this study we investigated the stability of the drug after dissolution to optimize its preparation for clinical use. It was shown to be stable for at least 90 days after preparation, and microbes did not grow in 1-10% (w/v) solutions (pH 2.0-2.5) regardless of the presence or absence of simple syrup. Furthermore, the autoclaved levocarnitine chloride solution was as stable as the non-autoclaved one. In conclusion, the method employed in our hospital for the preparation of levocarnitine chloride for infants is appropriate and is recommended as a standard medicine supply method among different facilities.