Faculty Information - SAWAMOTO Atsushi

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E-mail Address

Educational Background

Work experience /Academic appointments

Publications

（Last updated : 2025-07-23 09:31:32）

SAWAMOTO Atsushi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Associate professor

E-mail Address

Educational Background

1.	2008/04～2014/03	Faculty of Pharmaceutical Science, Matsuyama University, Graduated,
2.	2014/04～2018/03	〔Doctorial Course〕, Clinical Pharmacy, Matsuyama University, Completed,

Work experience /Academic appointments

1.	2021/04～2022/09	Lecturer
2.	2022/10～	Associate Professor

Publications

1.	2025/07	Article	Second-Generation H1-Receptor Antagonists, Mequitazine, Azelastine and Desloratadine Activate Caspase-8, Caspase-3, and Gasdermin E and Induce Cell Death Showing Pyroptotic-Like Features in Macrophages at Excessively High Concentrations Biological and Pharmaceutical Bulletin 48(7),pp.1031-1039 (Collaboration)
2.	2025/02	Article	Reduction in MCP-1 production in preadipocytes is mediated by PPARγ activation and JNK/SIRT1 signaling Biochimica et Biophysica Acta (BBA) - General Subjects 1869(2),pp.130737 (Collaboration)
3.	2024/11	Article	Anti-Inflammatory and Neurotrophic Factor Production Effects of 3,5,6,7,8,3′,4′-Heptamethoxyflavone in the Hippocampus of Lipopolysaccharide-Induced Inflammation Model Mice Molecules 29(23),pp.5559 (Collaboration)
4.	2024/10	Article	Cloperastine Reduces IL-6 Expression via Akt/GSK3/Nrf2 Signaling in Monocytes/Macrophages and Ameliorates Symptoms in a Mouse Sepsis Model Induced by Lipopolysaccharide Biological and Pharmaceutical Bulletin 47,pp.1699-1707 (Collaboration)
5.	2024/10	Article	Benproperine reduces IL-6 levels via Akt signaling in monocyte/macrophage-lineage cells and reduces the mortality of mouse sepsis model induced by lipopolysaccharide Journal of Pharmacological Sciences 156(2),pp.125-133 (Collaboration)
6.	2024/03	Article	Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice The FASEB Journal 38(5),pp.e23542 (Collaboration)
7.	2024/03	Article	Sulconazole induces pyroptosis promoted by interferon- γ in monocyte/macrophage lineage cells Journal of Pharmacological Sciences 153(3),pp.166-174 (Collaboration)
8.	2023/03	Article	Effects of Citrus kawachiensis Peel in Frailty-like Model Mice Induced by Low Protein Nutrition Disorders Antioxidants 12(3),pp.779 (Collaboration)
9.	2023/02	Article	N-Caffeoyltryptophan enhances adipogenic differentiation in preadipocytes and improves glucose tolerance in mice Biochimica et Biophysica Acta (BBA) - General Subjects 1867(2),pp.130277 (Collaboration)
10.	2022/08	Article	Ibudilast Reduces IL-6 Levels and Ameliorates Symptoms in Lipopolysaccharide-Induced Sepsis Mice Biological and Pharmaceutical Bulletin 45(8),pp.1180-1184 (Collaboration)
11.	2022/05	Article	Beneficial effects of Citrus kawachiensis peel on neurogenesis in the hippocampus and gut microbiota changes in a chronic unpredictable mild stress mouse model neutracauticals 2(2),pp.91-101 (Collaboration)
12.	2021/12	Article	Neuroprotective and Anti-Microglial Activation Effects of Tocotrienols in Brains of Lipopolysaccharide-Induced Inflammatory Model Mice neuroglia 2(1),pp.89-97 (Collaboration)
13.	2021/01	Article	T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning Biological and Pharmaceutical Bulletin 44(4),pp.550-556 (Collaboration)
14.	2021/01	Article	Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food Chemical and Pharmaceutical Bulletin 69(1),pp.2-10 (Collaboration)
15.	2020/10	Article	Cynandione A induces adipogenesis and beige adipocyte-related phenotype in 3T3-L1 cells Phytochemistry Letters 39,pp.84-89 (Collaboration)
16.	2020/03	Article	Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells Molecules 25(5),pp.1117 (Collaboration)
17.	2019/12	Article	Heptamethoxyflavone inhibits adipogenesis via enhancing PKA signaling European Journal of Pharmacology 865 (Collaboration)
18.	2019/12	Article	T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics Biomedical Research 40(6),pp.235-241 (Collaboration)
19.	2019/12	Article	Citrus Auraptene Induces Glial Cell Line-Derived Neurotrophic Factor in C6 Cells International Journal of Molecular Sciences 21(1),pp.253 (Collaboration)
20.	2019/08	Article	Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells Pharmacological reports 71(4),pp.653-658 (Collaboration)
21.	2019/04	Article	Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease J Nutr Sci Vitaminol 65(2),pp.205-208 (Collaboration)
22.	2019/04	Article	Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells Molecules 24(7),pp.1366 (Collaboration)
23.	2019/03	Article	Hydrolysable tannins, gallic acid, and ellagic acid in walnut reduced 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium bromide (MTT) reduction in T-Cells cultured from the spleen of mice. PharmaNutrition 7,pp.100140 (Collaboration)
24.	2019/02	Article	Auraptene/Naringin-Rich Fruit Juice of Citrus kawachiensis (Kawachi Bankan) Prevents Ischemia-Induced Neuronal Cell Death in Mouse Brain through Anti-Inflammatory Responses J Nutr Sci Vitaminol 65(1),pp.66-71 (Collaboration)
25.	2018/08	Article	Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice Antioxidants 7(8),pp.E109 (Collaboration)
26.	2018/08	Article	Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice Bioscience, Biotechnology, and Biochemistry 82(8),pp.1384-1395 (Collaboration)
27.	2018/07	Article	Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice Bioscience, Biotechnology, and Biochemistry 82(7),pp.1216-1224 (Collaboration)
28.	2018/05	Article	The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice Bioscience, Biotechnology, and Biochemistry 82(5),pp.869-878 (Collaboration)
29.	2018/01	Article	Sansoninto as evidence-based remedial medicine for depression-like behavior Journal of Natural Medicines 72(1),pp.118-126 (Collaboration)
30.	2017/10	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation International Journal of Molecular Sciences 18(10),pp.2133 (Collaboration)
31.	2017/02	Article	Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity International Journal of Molecular Sciences 18(3),pp.489 (Collaboration)
32.	2016/10	Article	Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease International Journal of Molecular Sciences 17(10),pp.1716 (Collaboration)
33.	2016/04	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus Molecules 21(4),pp.541 (Collaboration)
34.	2015/04	Article	Edaravone enhances brain-derived neurotrophic factor production in the ischemic mouse brain Pharmaceuticals 8(2),pp.176-185 (Collaboration)
35.	2014/05	Article	3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model Neurochemistry International 70,pp.30-38 (Collaboration)
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