Faculty Information - MITOME Hidemichi

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Membership of Professional Organizations

（Last updated : 2026-07-02 10:41:16）

MITOME Hidemichi
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Professor

Research Field (Keyword)

Pharmaceutical chemistry and drug development sciences, Pharmaceutical analytical chemistry and physicochemistry (Key Word：Analytical Chemistry, Organic Chemistry, Natural Products Chemistry)

Membership of Professional Organizations

1.	2004/05～	The Chemical Society of Japan
2.	2006/08～	The Japan Society for Analytical Chemistry
3.	2009/04～	Japan Society for Medical Application of Stable Isotope and Biogas

Publications

1.	2025/11	Article	Chemical instability of cefaclor in simple suspensions alkalinized with magnesium oxide and the structural elucidation of the degradation products Journal of Pharmaceutical Sciences 115(2),pp.104063 (Collaboration)
2.	2025/09	Article	Synthesis of [1-¹³C]2-oxoglutaric acid and ¹³C breath tests designed to assess TCA cycle flux Chemical and Pharmaceutical Bulletin 73(9),pp.807-812 (Collaboration)
3.	2025/08	Article	Effects of blood and brain midazolam concentrations on prolonged sedation in rats with low albumin levels Die Pharmazie - An International Journal of Pharmaceutical Sciences 80(4-8),pp.51-54 (Collaboration)
4.	2024/11	Article	Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide Journal of Pharmaceutical Health Care and Sciences 10(73) (Collaboration)
5.	2024/06	Article	Synthesis of biosynthetic intermediates of vibrioferrin and enzyme reactions using them as substrates Chemical and Pharmaceutical Bulletin 72(6),pp.559-565 (Collaboration)
6.	2024/01	Article	Preparation of [1'-¹³C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux Journal of Labelled Compounds and Radiopharmaceuticals 67(3),pp.86-90 (Collaboration)
7.	2023/12	Article	Analysis of the vibrioferrin biosynthetic pathway of Vibrio parahaemolyticus BioMetals 37,pp.507-517 (Collaboration)
8.	2023/08	Article	A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with Magnesium oxide. Journal of pharmaceutical health care and sciences 9(1),pp.32 (Collaboration)
9.	2023/02	Article	Study on the use of ozone water as a chemical decontamination agent for antineoplastic drugs in clinical settings Annals of Work Exposures and Health 67(2),pp.241-251 (Collaboration)
10.	2022/08	Article	Degradation and inactivation efficacy of ozone water for antineoplastic drugs in hospital settings Journal of Oncology Pharmacy Practice 28(8),pp.1781-1789 (Collaboration)
11.	2021/08	Article	Application of quantative NMR spectroscopy to the quality evaluation of diclofenac gargles as hospital preparations. Chemical & Pharmaceutical Bulletin 69(8),pp.721-726 (Collaboration)
12.	2016/04	Article	Amitorines A and B, Nitrogenous Diterpene Metabolites of Theonella swinhoei: Isolation, Structure Elucidation, and Asymmetric Synthesis Journal of Natural Products 79(4),pp.996-1004 (Collaboration)
13.	2014/08	Article	Synthesis of ¹³C-lidocaine as a probe of breath test for the evaluation of cytochrome P450 activity Chemical & Pharmaceutical Bulletin 62(8),pp.806-809 (Collaboration)
14.	2013/07	Article	Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using ¹H NMR spectroscopic urinalysis Journal of Pharmaceutical and Biomedical Analysis 85,pp.155-161 (Collaboration)
15.	2013/05	Article	An efficient laboratory-scale preparative method for [1-¹³C]glycocholic acid Journal of Labelled Compounds and Radiopharmaceuticals 56(11),pp.587-588 (Collaboration)
16.	2012/12	Article	Development and clinical application of a ¹³C-glycocholic acid breath test to diagnose bacterial overgrowth syndrome 安定同位体と生体ガス医学応用 4(1),pp.18-30 (Collaboration)
17.	2012/04	Article	A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on ¹H NMR spectroscopic urinalysis Hypertension Research 35(4),pp.404-412 (Collaboration)
18.	2012/03	Article	Sample preparation method to minimize chemical shift variability for NMR-based urinary metabonomics of genetically hypertensive rats Journal of Pharmaceutical and Biomedical Analysis 66,pp.339-344 (Collaboration)
19.	2012/01	Article	Briaroxalides: Novel Diepoxybriarane Diterpenes from an Okinawan Gorgonian Briareum Sp. Heterocycles 85(1),pp.135-145 (Collaboration)
20.	2011/12	Article	Total synthesis of antimalarial diterpenoid (+)-kalihinol A Chemical Communications 48(6),pp.901-903 (Collaboration)
21.	2011/02	Article	A formal synthesis of antimalarial diterpenoid 7,20-diisocyanoadociane. Chemistry Letters 40(3),pp.246-247 (Collaboration)
22.	2010/04	Article	LC-NMR identification of a novel taurine-related metabolite observed in ¹H NMR-based metabonomics of genetically hypertensive rats. Journal of Pharmaceutical and Biomedical Analysis 51(5),pp.1091-1096 (Collaboration)
23.	2008/05	Article	Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate. Chemical and pharmaceutical bulletin 56(5),pp.738-741 (Collaboration)
24.	2008/03	Article	¹H NMR-based metabonomic analysis of urine from young spontaneously hypertensive rats. Journal of Pharmaceutical and Biomedical Analysis 46(3),pp.550-556 (Collaboration)
25.	2006/01	Article	PLA₂ Inhibitory Activity of Marine Sesquiterpenoids Cladocorans, Their Diastereomers and Analogues Chem.Pharm.Bull. 54(2),pp.268-270 (Collaboration)
26.	2005/01	Article	8,17-Epoxybriarane diterpenoids, briaranolides A-J, from an Okinawan gorgonian Briareum sp. J. Nat. Prod. 68(9),pp.1328-1335 (Collaboration)
27.	2005/01	Article	N¹-Aminopropylagmatine, a New Polyamine Produced as a Key Intermediate in Polyamine Biosynthesis of an Extreme Thermophile, Thermus thermophilus J. Biol. Chem. 280(34),pp.30073-30082 (Collaboration)
28.	2005/01	Article	New Polyhydroxylated Sterols Stylisterols A-C and a Novel 5, 19-Cyclosterol Hatomasterol from the Okinawan Marine Sponge Stylissa sp. Steroids 70(1),pp.63-70 (Collaboration)
29.	2004/01	Article	Terpene Isocyanides, Isocyanates, and Isothiocyanates from the Okinawan Marine Sponge Stylissa sp. J. Nat. Prod. 67(5),pp.833-837 (Collaboration)
30.	2003/12	Article	New Strongylophorines from the Okinawan Marine Sponge Petrosia (Strongylophora) corticata. J. Nat. Prod. 66(12),pp.1600-1605 (Collaboration)
31.	2003/06	Article	Synthesis and Anti-tumor Activity of New Steroidal Nuclear Analogues of Aragusterol A. Chem.Pharm.Bull. 51(6),pp.640-645 (Collaboration)
32.	2003/01	Article	Total Syntesis of the Dolabellane Marine Diterpenoids, Clanone, Palominol and Dolabellatrienone Tetrahedron 59(1),pp.61-75 (Collaboration)
33.	2002/12	Article	A new Sesquiterpenoid Quinone and Other Related Compounds from the Okinawan Marine Sponge Dactylospongia elegans. J. Nat. Prod. 66(1),pp.46-50 (Collaboration)
34.	2002/10	Article	Total Syntesis and Absolute Configuration of Marine Bisnor-Diterpenoid Elisabethin C. Tetrahedron Lett. 43(43),pp.7773-7775 (Collaboration)
35.	2002/06	Article	Location of Functional Groups in Mycobacterial Meromycolate Chains; the Recognition of New Structural Principles in Mycolic Acids. Microbiology 148(6),pp.1881-1902 (Collaboration)
36.	2002/03	Article	Total Synthesis of Marine Diterpenoid Kalihinene X Tetrahedron Lett. 43(12),pp.2227-2230 (Collaboration)
37.	2002/02	Article	Dactyloquinone C, D and E; Novel Sesquiterpenoid Quinones, from the Okinawan Marine Sponge, Dactylospongia elegans. Tetrahedron 58(9),pp.1693-1696 (Collaboration)
38.	2001/12	Article	Total Synthesis of Marine Diterpenoid Strolonidiol. Tetrahedron Lett. 42(52),pp.9233-9236 (Collaboration)
39.	2001/11	Article	Dactyloquinones A and B, new Sesquiterpenoid Quinones from the Okinawan Marine Sponge, Dactylospongia elegans. J.Nat.Prod. 64(12),pp.1506-1508 (Collaboration)
40.	2001/05	Article	Pregnene derivatives from Solenostemma argel leaves Phytochemistry 57(4),pp.507-511 (Collaboration)
41.	2000/10	Article	Synthesis of the Optically Active Bicyclo[4.3.0]nonane Derivative, Regarded as the CD Ring Moiety of 12-Oxygenated Steroids Tetrahedron Lett. 41(42),pp.8107-8110 (Collaboration)
42.	2000/09	Article	Xeniaoxolane: A new xenicane-type diterpenoid from the Okinawan soft coral, Xenia sp.; Absolute Configurations of xeniaoxolane, xeniolide-A and xenialactol Tetrahedron 56(39),pp.7737-7740 (Collaboration)
43.	2000/08	Article	Three New Scalarane Sesquiterpenoids from the Okinawan Sponge Hyrtios erectus. J.Nat.Prod. 63(10),pp.1369-1372 (Collaboration)
44.	1997/07	Article	A Phenolic Cinnamate Dimer from Psoralea plicata. Phytochemistry 45(6),pp.1257-1261 (Collaboration)
45.	1997/04	Article	Aragusterols E-H, New 26, 27-Cyclosterols from the Okinawan Marine Sponge of the Genus Xestospongia and Absolute Configurations of Xestokerols A and B Tetrahedron 53(15),pp.5403-5412 (Collaboration)
46.	1997/03	Article	Synthesis of 5-Epiaragusterol A Bioorg. Med. Chem. Lett. 7(6),pp.691-692 (Collaboration)
47.	1996/09	Article	Triterpenoidal Saponin Glycosides from Glinus lotoides dictamnoides Phytochemistry 43(1),pp.183-188 (Collaboration)
48.	1996/03	Article	Two New Cembrane-type Diterpenoids from Okinawan Soft Coral of the Genus, Sarcophyton Chem. Lett. 25(3),pp.239-240 (Collaboration)
49.	1995/11	Article	Synthesis of Antitumor Marine Steroid Aragusterols Tetrahedron Lett. 36(45),pp.8231-8234 (Collaboration)
50.	1993/09	Article	Aragusterol A: a Potent Antitumor Marine Steroid from the Okinawan Sponge of the Genus, Xestospongia. Tetrahedron Lett. 34(39),pp.6277-6280 (Collaboration)
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