Faculty Information - TAMAI Eiji | Matsuyama University

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Research Field (Keyword)

Work experience /Academic appointments

Publications

（Last updated : 2025-11-17 15:21:46）

TAMAI Eiji
Department Matsuyama University School of Clinical Pharmacy, College of Pharmaceutical Sciences

Position Professor

Research Field (Keyword)

Bacteriology

Work experience /Academic appointments

1.	2007/04～2019/03	Matsuyama University College of Pharmaceutical Sciences School of Clinical Pharmacy Associate Professor
2.	2019/04～	Matsuyama University College of Pharmaceutical Sciences School of Clinical Pharmacy Professor

Publications

1.	2025/10	Article	Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile. Appl Environ Microbiol. 91(10),pp.e0121625 (Collaboration)
2.	2025/10	Article	Inhibition of Air-Exposure Stress-Induced Autolysis in Clostridium perfringens by Zn2. Acta Med Okayama. 79(5),pp.345-352 (Collaboration)
3.	2024/06	Article	X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain. Biochem Biophys Res Commun. (715),pp.149957 (Collaboration)
4.	2023/11	Article	Biochemical Characterizations of the Putative Amidase Endolysin Ecd18980 Catalytic Domain from Clostridioides difficile. Biol Pharm Bull. 46(11),pp.1625-1629 (Collaboration)
5.	2022/08	Article	Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile. Antibiotics (Basel). 11(8),pp.1131 (Collaboration)
6.	2021/10	Article	Structural and biochemical characterization of the Clostridium perfringens-specific Zn ²⁺-dependent amidase endolysin, Psa, catalytic domain Biochem Biophys Res Commun. 576,pp.66-72 (Collaboration)
7.	2021/05	Article	X-ray structures of Clostridium perfringens sortase C with C-terminal cell wall sorting motif of LPST demonstrate role of subsite for substrate-binding and structural variations of catalytic site 664,pp.138-144 (Collaboration)
8.	2021/04	Article	Structural and biochemical characterizations of the novel autolysin Acd24020 from Clostridioides difficile and its full-function catalytic domain as a lytic enzyme 115(4),pp.684-698 (Collaboration)
9.	2021/03	Article	A Putative Amidase Endolysin Encoded by Clostridium perfringens St13 Exhibits Specific Lytic Activity and Synergizes with the Muramidase Endolysin Psm Antibiotics 10(245),pp.1-14 (Collaboration)
10.	2020/09	Article	Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria Antibiotics 9(649),pp.1-12 (Collaboration)
11.	2019/08	Article	Structures of major pilins in Clostridium perfringens demonstrate dynamic conformational change. Acta Crystallogr D Struct Biol. 75(8),pp.718-732 (Collaboration)
12.	2018/11	Article	Benzoxazole-based Zn(II) and Cu(II) Complexes Overcome Multidrug-resistance in Cancer. Anticancer Res. 11(38),pp.6181-6187 (Collaboration)
13.	2018/07	Article	Synthesis and Antimicrobial Activity of 2-Trifluoroacetonylbenzoxazole Ligands and Their Metal Complexes. Chem Pharm Bull (Tokyo). 66(7),pp.732-740 (Collaboration)
14.	2018/05	Article	Expression of glyceraldehyde-3-phosphate dehydrogenase on the surface of Clostridium perfringens cells. Anaerobe 51,pp.124-130 (Collaboration)
15.	2017/11	Article	X-ray structure of Clostridium perfringens sortase B cysteine transpeptidase. Biochem. Biophys. Res. Commun. 439,pp.1267-1272 (Collaboration)
16.	2017/01	Article	Structural and biochemical characterization of the Clostridium perfringens autolysin catalytic domain. FEBS Lett. 591,pp.231-239 (Collaboration)
17.	2017/09	Article	Identification of Characteristic Phenolic Constituents in Mousouchiku Extract Used as Food Additives. Chem Pharm Bull (Tokyo). 65(9),pp.878-882 (Collaboration)
18.	2017/04	Article	A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem Pharm Bull (Tokyo). 65(4),pp.365-372 (Collaboration)
19.	2014/04	Article	X-ray structure of a novel endolysin encoded by episomal phage phiSM101 of Clostridium perfringens. Mol Microbiol. 92(2),pp.326-337 (Collaboration)
20.	2011/03	Article	High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens. Protein Expr Purif. 76(1),pp.83-89 (Collaboration)
21.	2011/02	Article	Development and Application of a Method for Counterselectable In-Frame Deletion in Clostridium perfringens. Appl Environ Microbiol. pp.1375-1382 (Collaboration)
22.	2011/01	Article	Identification and characterization of a putative endolysin encoded by episomal phage phiSM101 of Clostridium perfringens. Appl Microbiol Biotechnol. pp.1973-1979 (Collaboration)
23.	2010/10	Article	Identification and characterization of a Vibrio mimicus gene encoding the heme/hemoglobin receptor. Microbiol Immunol. pp.606-617 (Collaboration)
24.	2009/06	Article	Infections with gastrointestinal parasitic helminths indigenous to Japan and their treatment historically studied in an attempt to control the diseases in countries where they are still rampant: (1) the Jomon to Edo periods. Yakushigaku Zasshi. pp.18-23 (Collaboration)
25.	2008/12	Article	Construction of the curriculum and lectures for the subject, "History of pharmacy" in Matsuyama University School of Pharmacy. Yakushigaku Zasshi. pp.181-184 (Collaboration)
26.	2008/09	Article	High-level expression of his-tagged clostridial collagenase in Clostridium perfringens. Appl Microbiol Biotechnol. pp.627-635 (Collaboration)
27.	2008/01	Article	Construction and characterization of a clostripain-like protease-deficient mutant of Clostridium perfringens as a strain for clostridial gene expression. Appl Microbiol Biotechnol. pp.1063-1071 (Collaboration)
28.	2006/09	Article	Optimum preparation of levocarnitine chloride solution in the hospital pharmac pp.805-809 (Collaboration)
29.	2005/03	Article	Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells Microbiology and Immunology pp.245-253 (Collaboration)
30.	2004/10	Article	Genomic studies with Escherichia coli MelR protein : Applications of chromatin immunoprecipitation and microarrays Journal of Bacteriology pp.6938-6943 (Collaboration)
31.	2004/07	Article	High-level expression of clostridial sialidase using a ferredoxin gene promoter-based plasmid Protein Expression and Purification pp.70-75 (Collaboration)
32.	2003/11	Article	A novel type of DNA curvature present in a Clostridium perfringens ferredoxin gene: characterization and role in gene expression Microbiology pp.3083-3091 (Collaboration)
33.	2003/09	Article	Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance Infection and Immunity pp.5371-5375 (Collaboration)
34.	2014/12	Other	The visual recognition of parasitic helminths in Japan before the introduction of parasitology from Germany-A preliminary note on the confirmation from Jomon Period onward 松山大学論集 26(5),pp.231-248 (Collaboration)
35.	2012/05	Article	Food that needs precautionary awareness for infection in human body (6)- -Prevention from the infection with Gnathostoma hispidum Metagonimus (note) New Food Industry pp.25-28 (Collaboration)
36.	2012/04	Article	Food that needs precautionary awareness for infection in human body (5) - Prevention from the infection with Metagonimus spp. in several kinds of fresh-water fish(note) New Food Industry pp.39-45 (Collaboration)
37.	2012/03	Article	Bibliographical studies on Diphyllobothrium latum with special emphasis on the infection and treatment (Review) pp.9-14 (Collaboration)
38.	2012/02	Article	Food that needs precautionary awareness for infection in human body (4)- Prevention of people from the infection with Paragonimus westermanii in Japan(note) New Food Industry pp.36-40 (Collaboration)
39.	2011/11	Article	Food that needs precautionary awareness for infection in human body (3)- Prevention of people from the infection with Diphyllobothrium latum in Japan(note) New Food Industry pp.37-40 (Collaboration)
40.	2011/05	Article	Food that needs precautionary awareness for infection in human body (1)- Possible candidate as source of infection Angiostrongylus cantonensis (Note) New Food Industry pp.23-26 (Collaboration)
41.	2010/08	Article	Extended Inclusion of Medical Parasitology in the Education in School of Pharmacy, Matsuyama University Japanese Journal of Social Pharmacy pp.31-39 (Collaboration)
42.	2010/03	Article	A growing need for international cooperative studies to establish medicinal-plant therapy against obstinate and biohazardous nematodes in the tropical and subtropical areas and in Japan Japanese Journal of Social Pharmacy pp.11-21 (Collaboration)
43.	2003/04	Other	Cytotoxicity of $\epsilon$-toxin is altered by lipid microenvironments of target cell membranes
44.	2003/04	Other	The molecular mechanism of Clostridium perfringens epsilon-toxin cytotoxicity
45.	2002/10	Article	Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes The Journal of Biological Chemistry pp.39463-39468 (Collaboration)
46.	2002/07	Article	Purification, reconstitution, and characterization of Na+/serine symporter, SstT, of Escherichia coli Journal of Biochemistry (Tokyo) pp.71-76 (Collaboration)
47.	2001/12	Article	Phased A-tracts bind to the alpha subunit of RNA polymerase with increased affinity at low temperature FEBS Letter pp.235-238 (Collaboration)
48.	2000/06	Article	Mutations that increase the activity of promoter of the Escherichia coli melibiose operon improve the binding of MelR, a transcription activator triggered by melibiose The Journal of Biological Chemistry pp.17058-17063 (Collaboration)
49.	1999/08	Article	Melibiose carrier of Escherichia coli:use of cysteine mutagenesis to identify the amino acids on the hydrophilic face of transmembrane helix 2 Biochimica et Biophysica Acta pp.63-72 (Collaboration)
50.	1998/07	Article	Conversion of temperature-sensitive to-resistant gene expression due to mutations in the promoter region of the melibiose operon in Escherichia coli The Journal of Biological Chemistry pp.16860-16864 (Collaboration)
51.	1997/07	Article	Purification of UhpT, the sugar phosphate transporter of Escherichia coli Protein Expression and Purification pp.275-282 (Collaboration)
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